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CAS 75-65-0

tert-Butyl alcohol (tert-Butanol)

Tert-butyl alcohol (TBA) is a colorless industrial solvent and chemical intermediate that can also form when the gasoline additive MTBE breaks down in the environment [1][2]. Short, high-level exposure can irritate eyes and airways and affect the nervous system [3].

Where It Comes From

Made for use as a solvent and intermediate in manufacturing; also a common breakdown product of MTBE/ETBE in groundwater near fuel releases [1][2].

How You Are Exposed

Breathing vapors at work or during product use, skin contact with liquid, or drinking well water impacted by fuel-oxygenate contamination [1][2][3].

Why It Matters

Short-term exposure may cause irritation, headache, dizziness, and nausea; very high levels can depress the central nervous system [3]. Long-term animal studies found kidney/liver effects and tumors [1][4].

Who Is at Risk

Workers in fuel, solvent, and lab settings; people using private wells near leaking underground storage tanks or MTBE plumes [2][3].

How to Lower Your Exposure

Use in well-ventilated areas; keep containers closed; wear appropriate PPE at work [3]. If near known MTBE/TBA contamination, test private wells and use safe alternative or certified treatment [2].

References

  1. [1]ATSDR. ToxFAQs for tert-Butyl Alcohol (TBA). Agency for Toxic Substances and Disease Registry.
  2. [2]EPA. Technical Fact Sheet – Tert-Butyl Alcohol (TBA). U.S. Environmental Protection Agency.
  3. [3]CDC/NIOSH. NIOSH Pocket Guide to Chemical Hazards: tert-Butyl alcohol. Centers for Disease Control and Prevention.
  4. [4]NTP. Toxicology and Carcinogenesis Studies of tert-Butyl Alcohol (CAS 75-65-0) in Rats and Mice (TR-640). National Toxicology Program.

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