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CAS 10043-92-2

Radon (Rn-222)

RadionuclideRadioactive GasCarcinogenIndoor Air Pollutant

Radon is a colorless, odorless radioactive gas that seeps from uranium-bearing rocks and soil into homes — and is the second leading cause of lung cancer in the United States after smoking, responsible for approximately 21,000 lung cancer deaths per year, almost entirely preventable through testing and mitigation.

Where It Comes From

Radon is produced by the radioactive decay of uranium-238, which decays through radium-226 to radon-222 — a naturally occurring chain that has continued since Earth formed [1]. Uranium is present in trace amounts in almost all rocks and soils, but is concentrated in granite, phosphate deposits, and uranium-bearing shales. As radon gas forms underground, it diffuses through soil pores and rock fractures and can accumulate in buildings that sit over radon-emitting geology [2]. The U.S. EPA became aware of residential radon as a major health hazard in 1984 when a nuclear power plant worker named Stanley Watras repeatedly set off radiation detectors on his way INTO work — his home in Pennsylvania had radon levels 700 times the EPA action level [1]. The discovery galvanized a national radon testing program. Radon enters buildings through foundation cracks, pipe penetrations, sump pits, and construction joints [2].

How You Are Exposed

Indoor air in homes with poor foundation sealing is the dominant exposure route — radon accumulates in basements and lower floors where fresh air exchange is lowest [1]. Radon levels vary enormously: the U.S. average is ~1.3 pCi/L, but millions of homes exceed the EPA action level of 4 pCi/L, and some homes in high-radon geology (Iowa, Pennsylvania, Montana, Minnesota) reach 20-100+ pCi/L [2]. Well water from ground sources in high-radon areas contains dissolved radon that is released into air during showering and tap use, though this is a secondary contribution compared to soil entry [1]. Occupational exposure occurs in uranium miners (historically very high doses), underground miners, and cave tour guides [2].

Why It Matters

Radon doesn't cause harm as a gas — its decay products (polonium-218, lead-214, bismuth-214, polonium-214) do [1]. These short-lived radioactive progeny attach to airborne particles and, when inhaled, deposit on bronchial epithelium where they emit alpha particles. Alpha radiation is highly ionizing and causes DNA double-strand breaks in lung cells within millimeters of the decay site [2]. The link to lung cancer was confirmed by massive cohort studies of uranium miners; residential radon epidemiology (pooled analyses of over 7,000 lung cancer cases) confirmed the association at levels found in homes [1]. Radon and cigarette smoke act synergistically — a smoker in a high-radon home has roughly 10x the lung cancer risk of a nonsmoker in the same home [2].

Who Is at Risk

Smokers in high-radon homes face by far the greatest risk — the combination multiplies lung cancer risk dramatically [1]. Children's lungs are more sensitive to radiation-induced carcinogenesis due to rapid cell division during development. People who spend significant time in basements or lower floors of high-radon homes receive higher doses [2]. Residents in known high-radon geology (Iowa has the highest average state radon levels) should test as a priority. Underground miners who work in uranium or metal ore mining with inadequate ventilation face occupational exposures [1].

How to Lower Your Exposure

1. Test your home — radon testing is inexpensive ($10-30 for a DIY short-term test kit, available at hardware stores) and takes only 48 hours to 90 days depending on the kit type [1]. 2. If your test result is ≥4 pCi/L (EPA action level), hire a certified radon mitigation contractor — sub-slab depressurization systems (a pipe and fan that draw radon from under the foundation and vent it outdoors) reduce radon by 50-99% in virtually all homes [2]. 3. Mitigation systems cost $800-2,500 and last the life of the home with minimal maintenance. 4. Don't smoke and don't allow smoking in your home — radon and tobacco smoke together are exponentially more dangerous than either alone [1]. 5. Test after any major renovation that affects foundation or floor seals. 6. Retest every 2 years or after significant changes to the home [2].

References

  1. [1]EPA (2023). A Citizen's Guide to Radon. https://www.epa.gov/radon/citizens-guide-radon
  2. [2]Darby S et al. (2005). Radon in homes and risk of lung cancer. BMJ. https://doi.org/10.1136/bmj.38308.477650.63

Recovery & Clinical Information

Body Half-Life

Radon-222 itself has a physical half-life of 3.8 days; inhaled radon in the lungs is exhaled within minutes [1]. The hazard is from the short-lived decay products (polonium-218 half-life 3.1 min, lead-214 HL 26.8 min) that deposit in lung tissue [2].

Testing & Biomarkers

No clinical blood or urine test measures radon body burden [1]. Alpha track detectors and electret ion chambers measure radon in home air — this is the practical 'body burden' proxy [2]. For occupational miners, radon progeny exposure is measured in working level months (WLMs). Lung cancer surveillance (low-dose CT annually) is recommended for former uranium miners and for heavy smokers in high-radon homes [1].

Interventions

Sub-slab depressurization is the definitive intervention — eliminates ongoing radon exposure [1]. For past exposure: stop smoking immediately (this is the single most impactful action for anyone with prior radon exposure who smokes) [2]. Annual low-dose CT scan lung cancer screening is recommended for adults aged 50-80 with 20+ pack-year smoking history and should be discussed with high-radon-exposed nonsmokers too [1].

Recovery Timeline

Once a mitigation system is installed, indoor radon levels drop immediately — typically within hours [1]. The lung cancer risk from past radon exposure gradually diminishes over years after stopping exposure and smoking cessation, but does not immediately resolve [2].

Recovery References

  1. [1]EPA (2023). Radon Mitigation. https://www.epa.gov/radon
  2. [2]NCI (2023). Radon and Cancer. https://www.cancer.gov/about-cancer/causes-prevention/risk/radiation/radon-fact-sheet

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