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CAS 507-63-1

Perfluorooctyl iodide

Potential EDCPFAS

Perfluorooctyl iodide (PFOI) is a highly fluorinated industrial chemical used to make stain- and water-repellent coatings and fluoropolymers. It matters because it is a PFAS “precursor” that can transform into perfluorooctanoic acid (PFOA), a persistent pollutant with known health risks [1][2].

Where It Comes From

Fluorochemical manufacturing (telomerization); industrial emissions and wastes; residuals or breakdown of fluorotelomer-based products that can form PFOA in the environment [1][2].

How You Are Exposed

Mainly workers handling it; nearby communities via contaminated air, soil, or drinking water; possible low-level contact from PFAS-treated goods and indoor dust [1][2][3].

Why It Matters

Direct data on PFOI are limited, but PFOA (a likely product) causes cancer in humans (IARC Group 1) and immune, developmental, and liver effects; EPA set a very low drinking-water standard for PFOA [2][4][5][6].

Who Is at Risk

Fluorochemical workers; people near production or disposal sites; pregnant people, fetuses, and infants (PFAS can cross the placenta and enter breast milk) [1][2].

How to Lower Your Exposure

Check your water for PFAS; if elevated, use certified activated-carbon or reverse-osmosis filters; follow local fish advisories; reduce indoor dust with wet cleaning/HEPA vacuum; choose PFAS-free products when possible [2][3][6].

References

  1. [1]ATSDR. Toxicological Profile for Perfluoroalkyls (2021). https://www.atsdr.cdc.gov/toxprofiles/tp200.pdf
  2. [2]U.S. EPA. Understanding PFAS Risks. https://www.epa.gov/pfas/our-current-understanding-human-health-and-environmental-risks-pfas
  3. [3]U.S. EPA. Steps to Reduce Your Risk from PFAS. https://www.epa.gov/pfas/meaningful-and-achievable-steps-you-can-take-reduce-your-risk
  4. [4]IARC (2023). PFOA carcinogenic to humans (Group 1). https://www.iarc.who.int/news-events/iarc-monographs-evaluate-the-carcinogenicity-of-perfluorooctanoic-acid-pfoa-and-perfluorooctanesulfonic-acid-pfos/
  5. [5]NTP (2016). Immunotoxicity of PFOA and PFOS. https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf
  6. [6]U.S. EPA (2024). PFAS Drinking Water Regulation Fact Sheet. https://www.epa.gov/system/files/documents/2024-04/pfas_final_rule_factsheet_general_508_0.pdf

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