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CAS 104-12-1

p-Chlorophenyl isocyanate

p-Chlorophenyl isocyanate is a reactive industrial isocyanate used to make other chemicals. It can severely irritate eyes, skin, and lungs and can cause asthma after repeated or even small exposures [1][2].

Where It Comes From

Made for specialty chemical manufacturing and used in research/production; releases can occur during manufacturing, mixing, or spills [1][3].

How You Are Exposed

Mostly at work by breathing vapors/aerosols or via skin contact; the public is rarely exposed except near industrial sites or accidents [1][2].

Why It Matters

Causes burning eyes/skin, cough, wheeze, and chest tightness; can “sensitize” you so later tiny amounts trigger asthma; high exposures can injure lungs [1][2].

Who Is at Risk

Chemical plant and lab workers handling isocyanates; applicators of isocyanate-containing coatings; people with asthma/allergies; workers without good ventilation or PPE [1][2].

How to Lower Your Exposure

Use closed systems and local exhaust; wear chemical-resistant gloves, goggles, and protective clothing; use NIOSH-approved respirators when needed; get training, air monitoring, and medical surveillance; follow community alerts during incidents [1][2][3].

References

  1. [1]CDC/NIOSH. Isocyanates – Workplace Safety & Health Topic. https://www.cdc.gov/niosh/topics/isocyanates
  2. [2]ATSDR. Medical Management Guidelines for TDI/MDI. https://wwwn.cdc.gov/TSP/MMG/MMGDetails.aspx?mmgid=1006&toxid=208
  3. [3]U.S. EPA. Isocyanates Action Plan (2011). https://www.epa.gov/sites/default/files/2015-09/documents/isocyanates_actionplan_031611.pdf

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