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CAS 104-94-9

p-Anisidine

p-Anisidine (4-methoxyaniline) is a toxic aromatic amine used to make dyes and pharmaceuticals, and as a laboratory reagent. It can harm the blood and other organs; IARC classifies it as possibly carcinogenic to humans. [1][2]

Where It Comes From

Made for industrial use (dye/drug intermediates; lab reagent); releases can occur during manufacturing, processing, or waste handling. [1][3]

How You Are Exposed

Mostly at work by breathing vapors or dust and through skin contact; it can be absorbed through the skin. Nearby communities may be exposed after spills or emissions. [1]

Why It Matters

Can cause methemoglobinemia (reduced blood oxygen), headache, dizziness, bluish skin, and eye/skin irritation; repeated exposure may affect liver and kidneys. IARC: Group 2B (possible carcinogen). [1][2]

Who Is at Risk

Workers in dye, pharmaceutical, or lab settings using p‑anisidine; people with preexisting blood or breathing conditions may be more sensitive; lack of ventilation or protective gear raises risk. [1]

How to Lower Your Exposure

At work, use closed systems and local exhaust, chemical‑resistant gloves, goggles, and protective clothing; avoid skin contact and wash promptly; follow training and exposure limits. In communities, follow spill advisories and avoid contaminated areas. [1][3]

References

  1. [1]CDC/NIOSH. International Chemical Safety Card (ICSC) 0805: p‑Anisidine. https://www.cdc.gov/niosh/ipcsneng/neng0805.html
  2. [2]IARC Monographs. o‑Anisidine, p‑Anisidine, and their hydrochlorides (Group 2B). https://monographs.iarc.who.int
  3. [3]U.S. EPA CompTox Chemicals Dashboard: p‑Anisidine (CASRN 104-94-9). https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020250

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