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CAS 301-12-2

Oxydemeton-methyl

PesticidesFemale_Repro_ToxicityMale_Repro_Toxicity

Oxydemeton-methyl is a highly toxic organophosphate insecticide used to control aphids and mites on crops. It matters because it harms the nervous system by inhibiting cholinesterase, sometimes at very low doses [1][2].

Where It Comes From

Agricultural uses on vegetables, fruits, and ornamentals; some uses have been canceled or banned in several countries. Can appear as residues on imported produce and in air or water near treated fields [1][2].

How You Are Exposed

Mixing, loading, or spraying pesticides; touching recently treated plants or soil; breathing spray drift; eating contaminated produce; drinking contaminated water (less common) [1][3].

Why It Matters

Symptoms include headache, nausea, sweating, salivation, muscle twitching, breathing trouble, and seizures; severe poisoning can be fatal. Repeated exposure can depress cholinesterase and cause neurologic effects [1][3].

Who Is at Risk

Farmworkers and applicators; children; pregnant people; people with cholinesterase variants or on cholinesterase‑inhibiting medicines [1][3].

How to Lower Your Exposure

Workers—follow labels, use PPE (chemical‑resistant gloves, coveralls, eye protection, respirator as required), closed systems, and cholinesterase monitoring; observe restricted‑entry intervals. Public—avoid fields during/after spraying, wash/peel produce, heed local advisories, and seek medical care if symptoms occur [1][2][3].

References

  1. [1]US EPA. Oxydemeton-methyl Reregistration Eligibility Decision (RED), EPA 738-R-06-002, 2006.
  2. [2]WHO/FAO JMPR. Pesticide residues—Oxydemeton-methyl toxicology and residues evaluation.
  3. [3]ATSDR/CDC. Case Studies in Environmental Medicine: Cholinesterase Inhibitors (including organophosphate pesticides).

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