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CAS 528-29-0

o-Dinitrobenzene

o-Dinitrobenzene (1,2-dinitrobenzene) is a yellow industrial chemical used to make dyes, explosives, and other products. It is toxic because it can reduce the blood’s ability to carry oxygen (methemoglobinemia) and can affect the nervous system [1][2].

Where It Comes From

Made for dyes, explosives, and other chemicals; can enter air, water, or soil during manufacturing or spills, including at waste sites [1][3].

How You Are Exposed

Breathing workplace dust/vapor, skin contact, or drinking contaminated water near facilities or waste sites; routine consumer exposure is uncommon [1][2][3].

Why It Matters

Causes methemoglobinemia with headache, dizziness, blue skin, and shortness of breath; high doses may cause collapse. Repeated exposure can harm blood and nerves; some dinitrobenzenes affect male fertility in animals [1][2].

Who Is at Risk

Workers in dyes/explosives/chemical plants; people with G6PD deficiency, anemia, or heart/lung disease [1][2].

How to Lower Your Exposure

Work: use ventilation, gloves/goggles/protective clothing; avoid skin contact; wash up; don’t bring contaminated clothes home. Community: heed advisories, use alternate water if advised, report spills/odors [1][2][3].

References

  1. [1]ATSDR. Toxicological Profile for Dinitrobenzenes and Trinitrobenzenes.
  2. [2]CDC/NIOSH. Pocket Guide to Chemical Hazards: o-Dinitrobenzene (1,2-dinitrobenzene).
  3. [3]U.S. EPA. Hazard Summary: 1,2-Dinitrobenzene.

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