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CAS 12035-72-2

Nickel Subsulfide

Nickel subsulfide (Ni3S2) is a nickel compound used in nickel refining and other industrial processes. Breathing its dust or fumes can cause cancer, especially of the lung and nasal sinuses, and can irritate the lungs and skin [2][3][1].

Where It Comes From

Nickel smelting and refining; production of nickel powders and catalysts; byproduct of processing sulfide ores; emissions from refineries and some high‑temperature metalwork [1][2].

How You Are Exposed

Mainly at work by inhaling dust or fumes; less commonly by skin contact; people near facilities may have low‑level air or dust exposure; take‑home contamination on work clothes [1][2].

Why It Matters

Classified carcinogenic to humans; raises risk of lung and nasal/sinus cancer; can cause asthma‑like symptoms, chronic bronchitis, nasal irritation, and allergic skin rash in sensitized people [2][3][1].

Who Is at Risk

Workers in nickel smelting/refining, powder/catalyst manufacturing, electroplating, and other processing of nickel sulfide ores; smokers with workplace exposure; people with asthma or nickel allergy [1][2][4].

How to Lower Your Exposure

Use engineering controls and local exhaust; follow exposure limits and wear appropriate respirators and protective clothing; wash/shower and change before going home; employers should monitor air and provide training; nearby residents can reduce indoor dust by wet‑wiping, keeping outdoor dust out, and checking facility notices [1][4][5].

References

  1. [1]ATSDR. Toxicological Profile for Nickel. Agency for Toxic Substances and Disease Registry, 2022.
  2. [2]IARC. Nickel and Nickel Compounds. IARC Monographs, Volume 100C, 2012.
  3. [3]NTP. Report on Carcinogens, 15th Edition: Nickel Compounds. National Toxicology Program, 2021.
  4. [4]CDC/NIOSH. NIOSH Pocket Guide to Chemical Hazards: Nickel subsulfide (Ni3S2).
  5. [5]EPA IRIS. Nickel refinery dust and nickel subsulfide (CASRN 12035-72-2): Carcinogenicity assessment and unit risk. Environmental Protection Agency.

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