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CAS NDBA

NDBA

N-Nitrosodi-n-butylamine (NDBA) is a nitrosamine—a group of chemicals that can form as byproducts in industry and water treatment. It is toxic and has caused cancer in animals; IARC classifies NDBA as possibly carcinogenic to humans (Group 2B) [1][3].

Where It Comes From

Forms when amines react with nitrosating agents; found in rubber/chemical manufacturing, tobacco smoke, and can form at low levels during chloraminated drinking water and wastewater treatment [2][3].

How You Are Exposed

Drinking water in some systems, tobacco smoke, certain consumer products made from rubber, and workplace air in relevant industries [2][3].

Why It Matters

Long-term exposure increases cancer risk (especially liver; tumors seen in animals) and may harm the liver [1][3].

Who Is at Risk

Workers in rubber/chemical or water treatment facilities; people who smoke or breathe secondhand smoke; communities using chloraminated water; infants consuming formula mixed with affected tap water (higher dose per body weight) [2][3].

How to Lower Your Exposure

Avoid smoking and secondhand smoke; check your water utility’s reports for nitrosamines; consider a certified reverse osmosis device if nitrosamines are present; follow workplace controls and PPE; limit use of products that may release nitrosamines and ventilate well [2][3].

References

  1. [1]IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Some N-Nitroso Compounds, Vol. 17. International Agency for Research on Cancer.
  2. [2]U.S. EPA. Technical Fact Sheet – N-Nitrosamines (drinking water/wastewater formation, occurrence, treatment).
  3. [3]WHO/IPCS. Environmental Health Criteria 229: Selected Nitrosamines. World Health Organization.

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