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CAS 4549-40-0

N-Nitrosomethylvinylamine

N-Nitrosomethylvinylamine (NMVA) is a synthetic nitrosamine—a family of chemicals that can form unintentionally and are linked to cancer in animal studies [1][2]. NMVA is not made for consumer use; when detected, it’s usually as a trace byproduct where nitrosamines can form [2][3].

Where It Comes From

Forms when nitrite reacts with certain amines in industrial settings, tobacco smoke, or food processing; may also form during water treatment that uses chloramines [1][3][5].

How You Are Exposed

Day‑to‑day exposure is mainly to nitrosamines in general (tobacco smoke, some cured/processed foods, and occasionally drinking water or products). NMVA itself is seldom measured and expected at very low levels for most people [1][3][5].

Why It Matters

NMVA causes tumors in multiple animal studies; many nitrosamines damage DNA, so health agencies aim to minimize exposure even at low levels [2][4].

Who Is at Risk

People who smoke or are exposed to secondhand smoke; workers where amines and nitrosating agents are present (e.g., rubber/chemical manufacturing, wastewater treatment) [1][3][5].

How to Lower Your Exposure

Don’t smoke and avoid secondhand smoke; limit heavily cured or charred meats; check local water reports and consider certified activated carbon or reverse‑osmosis filters if nitrosamines are a concern; follow workplace controls (closed systems, ventilation, PPE) [1][3][5].

References

  1. [1]ATSDR. Toxicological Profile for N‑Nitrosodimethylamine (NDMA). 2022.
  2. [2]IARC. Some N‑Nitroso Compounds. IARC Monographs, Vol. 17; and Suppl. 7. 1978/1987.
  3. [3]U.S. EPA. Technical Fact Sheet – N‑Nitrosodimethylamine (NDMA). 2014.
  4. [4]NTP. Report on Carcinogens, 15th Ed. (entry on nitrosamines such as NDMA). 2021.
  5. [5]CDC/NIOSH. Current Intelligence Bulletin 15: Nitrosamines. 1976.

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