Where It Comes From
Forms when nitrite reacts with certain amines in industrial settings, tobacco smoke, or food processing; may also form during water treatment that uses chloramines [1][3][5].
How You Are Exposed
Day‑to‑day exposure is mainly to nitrosamines in general (tobacco smoke, some cured/processed foods, and occasionally drinking water or products). NMVA itself is seldom measured and expected at very low levels for most people [1][3][5].
Why It Matters
NMVA causes tumors in multiple animal studies; many nitrosamines damage DNA, so health agencies aim to minimize exposure even at low levels [2][4].
Who Is at Risk
People who smoke or are exposed to secondhand smoke; workers where amines and nitrosating agents are present (e.g., rubber/chemical manufacturing, wastewater treatment) [1][3][5].
How to Lower Your Exposure
Don’t smoke and avoid secondhand smoke; limit heavily cured or charred meats; check local water reports and consider certified activated carbon or reverse‑osmosis filters if nitrosamines are a concern; follow workplace controls (closed systems, ventilation, PPE) [1][3][5].
References
- [1]ATSDR. Toxicological Profile for N‑Nitrosodimethylamine (NDMA). 2022.
- [2]IARC. Some N‑Nitroso Compounds. IARC Monographs, Vol. 17; and Suppl. 7. 1978/1987.
- [3]U.S. EPA. Technical Fact Sheet – N‑Nitrosodimethylamine (NDMA). 2014.
- [4]NTP. Report on Carcinogens, 15th Ed. (entry on nitrosamines such as NDMA). 2021.
- [5]CDC/NIOSH. Current Intelligence Bulletin 15: Nitrosamines. 1976.