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CAS 1691-99-2

N-Ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide

N-Ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide (often called N‑EtFOSE) is a PFAS used in stain-, grease-, and water‑repellent treatments. It can break down into PFOS, a long‑lasting pollutant linked to health concerns [1][2].

Where It Comes From

Older stain‑resistant coatings for paper food packaging, textiles, carpets, and some coatings; manufacturing wastes and legacy products can release it to indoor dust and the environment [1][2].

How You Are Exposed

Breathing or ingesting indoor dust from treated items; contact with treated fabrics; eating food from grease‑resistant packaging; drinking contaminated water; workplace exposures in fluorochemical, paper, or textile finishing [1][2].

Why It Matters

Persistent and bioaccumulative; transforms to PFOS. PFOS exposure is associated with increased cholesterol, reduced vaccine response (immune effects), liver and thyroid changes, and developmental effects; some studies suggest higher risk of certain cancers [1][3].

Who Is at Risk

Workers handling fluorochemicals or stain‑repellent applications; people with older stain‑treated carpets/upholstery; communities with PFAS‑contaminated water; pregnant people, fetuses, and infants [1].

How to Lower Your Exposure

Choose PFAS‑free products; avoid legacy stain‑proof sprays; HEPA vacuum and wet‑dust; wash hands (especially children); limit grease‑resistant packaging; use certified home water filters (granular activated carbon or reverse osmosis) and check local PFAS water results [2][4].

References

  1. [1]ATSDR. Toxicological Profile for Perfluoroalkyls (Draft). 2021. https://www.atsdr.cdc.gov/toxprofiles/tp200.pdf
  2. [2]U.S. EPA. Long-Chain Perfluorinated Chemicals (PFCs) Action Plan. 2010. https://www.epa.gov/sites/default/files/2015-09/documents/pfcs_action_plan1230_09.pdf
  3. [3]NTP. Immunotoxicity Associated with Exposure to PFOA or PFOS. 2016. https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/completed/pfoa
  4. [4]U.S. EPA. Reducing PFAS in Your Drinking Water With Home Treatment Devices. 2023. https://www.epa.gov/system/files/documents/2023-09/reducing-pfas-in-drinking-water-with-home-treatment-devices.pdf

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