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CAS 376-27-2

Methyl perfluorooctanoate

Methyl perfluorooctanoate is a man-made PFAS chemical used in fluorochemical manufacturing. It is very persistent, and related PFAS can transform into perfluorooctanoic acid (PFOA), a well-studied toxic PFAS found in people and the environment [1]. PFOA is classified as carcinogenic to humans [2].

Where It Comes From

Fluorochemical production and processing; releases from facilities and breakdown of PFAS-treated products. This compound may act as a PFOA precursor [1].

How You Are Exposed

Drinking water near manufacturing or firefighting foam (AFFF) sites; food contact materials; indoor dust from stain- and water‑resistant products; certain workplaces [1][4].

Why It Matters

PFAS persist and can build up in people. PFOA exposure has been linked to higher cholesterol, immune effects (reduced vaccine response), liver and thyroid changes, pregnancy‑induced hypertension, and lower birth weight; it is carcinogenic to humans [1][2]. EPA now sets strict national drinking water standards for PFOA to reduce risk [3].

Who Is at Risk

People using contaminated private wells; communities near PFAS facilities or AFFF sites; workers handling PFAS; pregnant people and infants (including formula mixed with contaminated water) [1][4].

How to Lower Your Exposure

Check local water results; test private wells. Use NSF/ANSI‑certified reverse osmosis or activated carbon filters for PFAS. Follow water/fish advisories; limit stain‑/water‑resistant treatments; wet‑dust/HEPA vacuum; follow workplace safety practices [1][3][4][5].

References

  1. [1]ATSDR. Toxicological Profile for Perfluoroalkyls (including PFOA). 2021.
  2. [2]IARC. Monographs Vol. 135: Perfluorooctanoic acid (PFOA). 2023.
  3. [3]U.S. EPA. Final National Primary Drinking Water Regulation for PFAS (PFOA). 2024.
  4. [4]CDC/ATSDR. PFAS and Your Health (exposure, health effects, guidance).
  5. [5]U.S. EPA. Technical Fact Sheet: PFOA and PFOS (treatment and exposure).

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