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CAS 94-74-6

Methoxone (MCPA)

PesticidesCarcinogen

MCPA (often sold under various brand names, including Methoxone) is a common herbicide used to kill broadleaf weeds in lawns, pastures, and crops. It matters because it can irritate skin and eyes and, at higher doses, affect the liver and nervous system [1][2].

Where It Comes From

Spraying on turf, fields, and roadsides; it can run off into streams or seep into shallow wells after use [1][2].

How You Are Exposed

Skin contact or breathing spray during application; touching treated grass before it’s dry; drift from nearby spraying; drinking contaminated private well water. Food residues are regulated and typically low [1][2].

Why It Matters

Short-term exposure can cause irritation, nausea, vomiting, headache, or dizziness; severe poisoning is uncommon but more serious effects can occur at high doses [2]. IARC found evidence inadequate to classify MCPA’s carcinogenicity; EPA assessments indicate typical community exposures are below levels of concern when used as directed [1][3].

Who Is at Risk

Applicators and farmworkers; people living near frequent spraying; children and pets on recently treated lawns; households with shallow/private wells near treated fields [1][2].

How to Lower Your Exposure

Follow label directions; avoid treated areas until dry or the reentry interval ends; use protective gear when applying; close windows during nearby spraying; wash hands and produce; test private well water if you live near heavy use [1][2].

References

  1. [1]U.S. EPA. Reregistration Eligibility Decision (RED) for MCPA and Human Health Risk Assessments (2004 and updates). https://www.epa.gov
  2. [2]WHO/IPCS. Poisons Information Monograph: MCPA (PIM 332). INCHEM. https://inchem.org
  3. [3]IARC. Monographs on the Evaluation of Carcinogenic Risks: Chlorophenoxy herbicides (includes MCPA) – evaluation indicates inadequate evidence in humans. https://monographs.iarc.who.int

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