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CAS 16984-48-8

FLUORIDE

Fluoride is a naturally occurring mineral added to some drinking water and dental products to prevent cavities. Too much fluoride can harm teeth and bones, and high exposures have been linked to possible effects on brain development in children [1][5].

Where It Comes From

Natural groundwater, community water fluoridation, toothpaste/mouth rinses, tea and some foods, and emissions from aluminum and phosphate fertilizer industries [1][4].

How You Are Exposed

Drinking water (main source), swallowing dental products, food/tea, and workplace air in certain industries [1][4].

Why It Matters

High levels cause dental fluorosis; very high, long-term intake can cause skeletal fluorosis [1][3]. EPA’s drinking-water limit is 4.0 mg/L (with a 2.0 mg/L secondary standard for cosmetic effects) [2]. NTP finds fluoride is presumed to be a developmental neurotoxicant at elevated exposures [5].

Who Is at Risk

Young children, infants fed formula mixed with fluoridated water, people with kidney disease, private well users in high‑fluoride areas, certain industrial workers, heavy tea drinkers [1][3][4].

How to Lower Your Exposure

Check your water’s fluoride (utility Consumer Confidence Report or test private wells) [2]. If high, consider reverse osmosis or activated alumina treatment [3]. Use a pea‑sized dab of toothpaste, supervise children, don’t swallow, and consider low‑fluoride water for infant formula [4][1].

References

  1. [1]ATSDR. Toxicological Profile for Fluorides, Hydrogen Fluoride, and Fluorine. Agency for Toxic Substances and Disease Registry, 2003.
  2. [2]EPA. National Primary Drinking Water Regulations: Fluoride (MCL 4.0 mg/L; SMCL 2.0 mg/L). U.S. Environmental Protection Agency.
  3. [3]WHO. Guidelines for Drinking-water Quality, 4th ed. incorporating the 1st addendum. World Health Organization, 2017. Guideline value: 1.5 mg/L.
  4. [4]CDC. Community Water Fluoridation; Using Fluoride Toothpaste. Centers for Disease Control and Prevention.
  5. [5]NTP. Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects. National Toxicology Program, 2020.

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