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CAS 107-21-1

Ethylene glycol

Ethylene glycol is a toxic, sweet-tasting liquid used mostly in antifreeze and aircraft de-icing. It matters because swallowing even small amounts can cause life-threatening poisoning and kidney failure without quick treatment [1][2].

Where It Comes From

Vehicle coolants/antifreeze, de-icing fluids, some brake fluids, and in making polyester resins [1][3].

How You Are Exposed

Mainly by swallowing (accidental or intentional); less often by breathing mists at work or through skin contact with liquid or vapor [1][2].

Why It Matters

Breaks down in the body to acids that can cause nausea, confusion, metabolic acidosis, and serious kidney damage or failure; can be fatal [1][3].

Who Is at Risk

Children and pets around garages, people who store or decant antifreeze at home, auto/aircraft maintenance workers, and anyone using non-beverage alcohol substitutes [1][2].

How to Lower Your Exposure

Store products in original, child-resistant containers; keep locked away; clean spills promptly; never put into drink bottles; maintain vehicles to prevent leaks; at work, use gloves/eye protection and ventilation as recommended on safety data sheets [1][2]. Where appropriate, consider propylene glycol–based antifreeze, which is less toxic if swallowed [1].

References

  1. [1]ATSDR. ToxFAQs for Ethylene Glycol and Propylene Glycol. Agency for Toxic Substances and Disease Registry.
  2. [2]CDC/NIOSH. Ethylene Glycol (NIOSH Pocket Guide to Chemical Hazards).
  3. [3]WHO. Ethylene Glycol in Drinking-water: Background document for development of WHO Guidelines for Drinking-water Quality. World Health Organization.

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