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CAS 474-86-2

EQUILIN

Organic Chemicals, except for PFASPotential EDC

Equilin is a steroid estrogen found in pregnant mares’ urine and used in some menopausal hormone medicines (conjugated equine estrogens) [5]. It is biologically active and can affect health and ecosystems at low levels [1][3].

Where It Comes From

Prescription hormone therapy products containing conjugated equine estrogens; excretion after use to wastewater; releases from drug manufacturing and healthcare waste [3][4][5].

How You Are Exposed

Taking these medicines; skin contact with hormone pills/creams; occupational handling in pharmacies, hospitals, or long‑term care; trace amounts may occur in water downstream of wastewater plants (typically very low) [3][4].

Why It Matters

Steroidal estrogens are known human carcinogens; menopausal hormone therapy with estrogens increases risks for breast and endometrial cancers [1][2]. Estrogenic hormones can also disrupt fish reproduction [3].

Who Is at Risk

People using estrogen therapy; healthcare and pharmacy workers who handle or clean up these drugs [2][4].

How to Lower Your Exposure

Use only as prescribed; avoid touching others’ hormone meds; do not flush—use drug take‑back or local disposal guidance; workers should follow NIOSH hazardous‑drug precautions (PPE, engineering controls) [3][4].

References

  1. [1]NTP. Report on Carcinogens: Steroidal Estrogens (Known to be Human Carcinogens).
  2. [2]IARC Monographs Vol. 91. Combined Estrogen–Progestogen Menopausal Therapy; Estrogen-only Therapy.
  3. [3]WHO. Pharmaceuticals in Drinking-water. 2012.
  4. [4]CDC/NIOSH. NIOSH List of Hazardous Drugs in Healthcare Settings. 2020.
  5. [5]NIH PubChem. Equilin (CID 10134) Compound Summary.

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