Where It Comes From
Prescription hormone therapy products containing conjugated equine estrogens; excretion after use to wastewater; releases from drug manufacturing and healthcare waste [3][4][5].
How You Are Exposed
Taking these medicines; skin contact with hormone pills/creams; occupational handling in pharmacies, hospitals, or long‑term care; trace amounts may occur in water downstream of wastewater plants (typically very low) [3][4].
Why It Matters
Steroidal estrogens are known human carcinogens; menopausal hormone therapy with estrogens increases risks for breast and endometrial cancers [1][2]. Estrogenic hormones can also disrupt fish reproduction [3].
Who Is at Risk
People using estrogen therapy; healthcare and pharmacy workers who handle or clean up these drugs [2][4].
How to Lower Your Exposure
Use only as prescribed; avoid touching others’ hormone meds; do not flush—use drug take‑back or local disposal guidance; workers should follow NIOSH hazardous‑drug precautions (PPE, engineering controls) [3][4].
References
- [1]NTP. Report on Carcinogens: Steroidal Estrogens (Known to be Human Carcinogens).
- [2]IARC Monographs Vol. 91. Combined Estrogen–Progestogen Menopausal Therapy; Estrogen-only Therapy.
- [3]WHO. Pharmaceuticals in Drinking-water. 2012.
- [4]CDC/NIOSH. NIOSH List of Hazardous Drugs in Healthcare Settings. 2020.
- [5]NIH PubChem. Equilin (CID 10134) Compound Summary.