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CAS 77-78-1

Dimethyl sulfate

CarcinogenCorrosiveMutagenTeratogen

Dimethyl sulfate is a highly toxic industrial chemical used to make dyes, medicines, and other products. It can severely damage eyes, skin, and lungs, and repeated exposure may increase cancer risk [3][1][2].

Where It Comes From

Made and used in chemical manufacturing as a methylating agent; not intended for consumer use; breaks down in moisture but can pose acute hazard near releases [4].

How You Are Exposed

Mainly by breathing vapors or skin contact at work; nearby communities are exposed only during spills or accidents; you can’t rely on smell to warn you [3][4].

Why It Matters

Causes severe burns and delayed lung injury that can be life‑threatening after a few hours; classified as probably carcinogenic (IARC) and reasonably anticipated human carcinogen (NTP) [3][1][2].

Who Is at Risk

Workers in chemical plants and labs, emergency responders, and people near an industrial release; those with asthma or lung disease may be more sensitive [3][4].

How to Lower Your Exposure

For workers—use closed systems, local exhaust, chemical‑resistant gloves/clothing, and appropriate respirators; get training and emergency decontamination plans. For communities during a release—go indoors, close windows/HVAC, move upwind if told, and rinse skin/eyes promptly if contacted [3][4].

References

  1. [1]IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 71 (1999): Dialkyl sulfates (incl. Dimethyl sulfate), WHO/IARC.
  2. [2]U.S. National Toxicology Program (NTP). Report on Carcinogens, 15th Edition (2021): Dimethyl sulfate.
  3. [3]CDC/NIOSH. Pocket Guide and IDLH documentation: Dimethyl sulfate.
  4. [4]WHO IPCS/ILO. International Chemical Safety Card (ICSC) 0346: Dimethyl sulfate.

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