Where It Comes From
Made by hydrogenating safrole (a natural component of some essential oils like sassafras); used in fragrance and as a chemical intermediate [1][3].
How You Are Exposed
Mainly at work in fragrance, flavor, or chemical manufacturing; the public may encounter small amounts from scented products or essential oils. Exposure can occur by breathing vapors or skin contact.
Why It Matters
Animal data suggest liver effects at high doses; human data are insufficient. IARC classifies dihydrosafrole as “not classifiable as to its carcinogenicity to humans” (Group 3) [1][2].
Who Is at Risk
Workers handling the chemical; people using many fragranced or essential‑oil products in small, poorly ventilated spaces; those with liver disease; pregnant people and young children.
How to Lower Your Exposure
Choose fragrance‑free products, ventilate when using scented items, store chemicals sealed, and wash skin after contact. At work, use local exhaust ventilation, gloves, and follow your safety data sheet and training.
References
- [1]IARC Monographs, Volume 10: Some Naturally Occurring Substances (includes dihydrosafrole). International Agency for Research on Cancer, 1976.
- [2]IARC Monographs, Supplement 7: Overall Evaluations. IARC, 1987 (dihydrosafrole: Group 3).
- [3]WHO/FAO JECFA evaluations on safrole and related flavouring substances (context for sources and use).
- [4]EPA IRIS (safrole) – background on related compound and liver effects. Environmental Protection Agency.