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CAS 1464-53-5

Diepoxybutane

Diepoxybutane (DEB) is a highly reactive industrial chemical that powerfully damages DNA. It’s also formed in the body after exposure to 1,3‑butadiene, so it matters for certain workers and nearby communities [2][3].

Where It Comes From

Made for chemical synthesis and lab cross‑linking; also formed metabolically from 1,3‑butadiene found in petrochemical emissions and cigarette smoke [2][3].

How You Are Exposed

Breathing workplace air or through skin contact during manufacturing, lab handling, or spills; the public is mainly exposed indirectly via 1,3‑butadiene that the body converts to DEB [1][3].

Why It Matters

Irritates eyes/skin/lungs and strongly cross‑links DNA (mutagen). NIOSH treats DEB as a potential occupational carcinogen; its genotoxicity contributes to cancer risk associated with butadiene exposure [1][2][3].

Who Is at Risk

Workers in petrochemical, polymer/rubber, and research labs; smokers; people living near facilities emitting 1,3‑butadiene [1][3].

How to Lower Your Exposure

At work, use closed systems, local exhaust, and protective gloves/eye protection; avoid skin contact and clean spills promptly. Follow workplace exposure controls and medical surveillance if offered [1]. For the public, reduce tobacco smoke exposure and time near heavy traffic/industrial plumes; follow local air quality advisories [3].

References

  1. [1]CDC/NIOSH. NIOSH Pocket Guide to Chemical Hazards: 1,2:3,4-Diepoxybutane.
  2. [2]IARC. Monographs Vol. 97: 1,3‑Butadiene, Ethylene Oxide, and Vinyl Halides. 2008.
  3. [3]ATSDR. Toxicological Profile for 1,3‑Butadiene. 2021.
  4. [4]NIH/NLM. PubChem Compound Summary: 1,2:3,4‑Diepoxybutane (CID 10140).

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