Where It Comes From
Made for chemical synthesis and lab cross‑linking; also formed metabolically from 1,3‑butadiene found in petrochemical emissions and cigarette smoke [2][3].
How You Are Exposed
Breathing workplace air or through skin contact during manufacturing, lab handling, or spills; the public is mainly exposed indirectly via 1,3‑butadiene that the body converts to DEB [1][3].
Why It Matters
Irritates eyes/skin/lungs and strongly cross‑links DNA (mutagen). NIOSH treats DEB as a potential occupational carcinogen; its genotoxicity contributes to cancer risk associated with butadiene exposure [1][2][3].
Who Is at Risk
Workers in petrochemical, polymer/rubber, and research labs; smokers; people living near facilities emitting 1,3‑butadiene [1][3].
How to Lower Your Exposure
At work, use closed systems, local exhaust, and protective gloves/eye protection; avoid skin contact and clean spills promptly. Follow workplace exposure controls and medical surveillance if offered [1]. For the public, reduce tobacco smoke exposure and time near heavy traffic/industrial plumes; follow local air quality advisories [3].
References
- [1]CDC/NIOSH. NIOSH Pocket Guide to Chemical Hazards: 1,2:3,4-Diepoxybutane.
- [2]IARC. Monographs Vol. 97: 1,3‑Butadiene, Ethylene Oxide, and Vinyl Halides. 2008.
- [3]ATSDR. Toxicological Profile for 1,3‑Butadiene. 2021.
- [4]NIH/NLM. PubChem Compound Summary: 1,2:3,4‑Diepoxybutane (CID 10140).