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CAS 75-71-8

Dichlorodifluoromethane (CFC-12)

Dichlorodifluoromethane (CFC-12) is a colorless gas once widely used as a refrigerant (R-12) and aerosol propellant. At high levels it can displace oxygen and affect the heart and nervous system; releases also damage the ozone layer, increasing harmful UV radiation. [1][2][3]

Where It Comes From

Leaks or venting from older R‑12 refrigerators, freezers, and car A/C systems, and some legacy aerosol products. [1][3]

How You Are Exposed

Breathing air in poorly ventilated areas during equipment leaks, servicing, or disposal; accidental releases in enclosed spaces. [1][2]

Why It Matters

High exposures can cause dizziness, confusion, fainting, irregular heartbeat, and frostbite from liquid contact; extreme concentrations can asphyxiate. Ozone depletion from CFC‑12 increases skin cancer and cataract risk. [2][3]

Who Is at Risk

Workers who service, repair, or scrap older refrigeration/auto A/C equipment; people near leaks in small rooms. [1][2]

How to Lower Your Exposure

Replace or retrofit old R‑12 units; use certified technicians to recover refrigerant (no venting); ensure good ventilation; follow PPE and safe‑work practices when handling refrigerants. [2][3]

References

  1. [1]ATSDR. ToxFAQs for Chlorofluorocarbons (CFCs). Agency for Toxic Substances and Disease Registry. https://www.atsdr.cdc.gov/toxfaqs/
  2. [2]CDC/NIOSH. NIOSH Pocket Guide to Chemical Hazards: Dichlorodifluoromethane. https://www.cdc.gov/niosh/npg/
  3. [3]U.S. EPA. Health and Environmental Effects of Ozone Layer Depletion; and Class I Ozone-Depleting Substances (CFC‑12). https://www.epa.gov/ozone-layer-protection/health-and-environmental-effects-ozone-layer-depletion; https://www.epa.gov/ozone-layer-protection/ozone-depleting-substances#classI

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