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CAS 5598-13-0

Chlorpyrifos-methyl

Potential EDCPesticides

Chlorpyrifos-methyl is a toxic organophosphate insecticide used on crops and stored grain. It harms the nervous system by blocking an enzyme needed for normal nerve function [1][2].

Where It Comes From

Agricultural use on cereals, oilseeds, and post-harvest grain treatments; residues can occur in soil, dust, and water near treated areas [1][2].

How You Are Exposed

Eating treated foods; breathing or touching contaminated air or dust during or after application; occupational mixing, loading, or applying products [1][3].

Why It Matters

Short-term exposure can cause headache, nausea, sweating, and dizziness; high doses may lead to breathing trouble and seizures. Repeated exposure can depress cholinesterase and affect the nervous system [1][2][3].

Who Is at Risk

Farmworkers, applicators, and grain handlers; children and pregnant people; individuals with lower detoxification capacity (e.g., low PON1 activity) [2][3].

How to Lower Your Exposure

Follow label directions and re-entry intervals; use protective gear; keep children and pets away from treated areas; ventilate storage areas; wash hands and rinse produce; consider integrated pest management and safer alternatives [1][3].

References

  1. [1]U.S. EPA. Chlorpyrifos-methyl: Human Health Risk Assessment for Registration Review. Office of Pesticide Programs; 2014.
  2. [2]WHO/FAO JMPR. Chlorpyrifos-methyl: Toxicological evaluation (Pesticide Residues in Food—1996 Evaluations). World Health Organization; 1996.
  3. [3]ATSDR. ToxFAQs: Organophosphate Insecticides. Agency for Toxic Substances and Disease Registry; 2021.

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