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CAS 75-45-6

Chlorodifluoromethane (HCFC-22)

Organic Chemicals, except for PFASVOC

HCFC-22 (also called R‑22) is a refrigerant that was widely used in air conditioners and heat pumps. At high levels it can be harmful to health and it damages the ozone layer, so it’s being phased out. [1][2]

Where It Comes From

Leaks and releases from older cooling equipment and during servicing; industrial use as a feedstock to make fluoropolymers; legacy foam insulation. [1][2]

How You Are Exposed

Breathing air near a leak, especially indoors or in confined spaces; during equipment maintenance; skin/eye contact with the very cold liquid. [1][3]

Why It Matters

Can displace oxygen and cause dizziness, headache, and confusion; very high levels may trigger irregular heartbeat, unconsciousness, or death; liquid can cause frostbite. Environmentally, it depletes ozone and is a potent greenhouse gas. [1][3][2]

Who Is at Risk

HVAC/refrigeration workers; people in small or poorly ventilated rooms with older R‑22 units; workers making or transporting the gas; people with heart disease or using stimulants; anyone who intentionally inhales refrigerants. [1][3]

How to Lower Your Exposure

Repair leaks promptly; use certified technicians; ensure good ventilation; replace aging R‑22 equipment with non‑ozone‑depleting alternatives; follow EPA rules for recovery and disposal; never inhale refrigerants. [2][3][1]

References

  1. [1]ATSDR. ToxFAQs for Hydrochlorofluorocarbons (HCFCs). Agency for Toxic Substances and Disease Registry.
  2. [2]U.S. EPA. Phaseout of HCFCs (including R‑22) and ozone layer protection resources.
  3. [3]CDC/NIOSH. Pocket Guide to Chemical Hazards: Chlorodifluoromethane (R‑22).

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