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CAS 7440-38-2

Arsenic

carcinogenheavy metaldrinking water contaminantpesticide

Arsenic is a naturally occurring metalloid that has poisoned drinking water supplies for millions of people worldwide — and it may be in your tap water right now. Long-term exposure, even at low levels, raises your risk of bladder, lung, and skin cancers along with heart disease and diabetes.

Where It Comes From

Arsenic's toxic history stretches back to ancient Rome, where it was called the "inheritance powder" — a favored tool of poisoners precisely because it mimicked natural illness [1]. Industrially, arsenic exploded into global use in the 19th century as an agricultural pesticide and wood preservative (CCA-treated lumber), contaminating soil at millions of sites across the US [2]. The bigger story today is geology: arsenic occurs naturally in bedrock, and as groundwater dissolves rock over millennia, it concentrates in wells across Bangladesh, India, and the American West and Midwest. The 2001 discovery that tens of millions of Bangladeshis were being slowly poisoned by their own government-drilled wells — meant to prevent waterborne disease — became one of the largest mass poisonings in history [3]. In the US, the EPA estimates 13 million people drink water with arsenic above the 10 ppb limit, mostly from private wells in states like Nevada, Maine, and Michigan [4].

How You Are Exposed

Your biggest risk is drinking water from a private well, especially if you live in New England, the upper Midwest, or the Southwest — regions where arsenic-bearing bedrock is common [1]. But municipal water is not entirely safe: older systems sometimes exceed the 10 ppb federal limit. Food is the second major route — rice accumulates arsenic from paddy water, and apple and grape juice historically had elevated levels [2]. Pressure-treated lumber installed before 2004 used arsenic compounds; if your deck or playground equipment is from that era, handling and weathering can expose nearby soil [3]. Occupational exposure is highest in mining, smelting, glass manufacturing, and semiconductor production. Tobacco also contains arsenic — yet another reason to avoid smoke.

Why It Matters

Arsenic doesn't kill quickly — it accumulates in your hair, nails, and skin over years while silently damaging multiple organ systems [1]. It works by interfering with how your cells produce energy, disrupting enzymes that your body relies on for basic metabolism. Long-term exposure at levels as low as 10 ppb in drinking water increases your lifetime risk of bladder, lung, and skin cancer. Beyond cancer, arsenic hardens arteries and raises the risk of heart attack, damages insulin-producing cells to cause Type 2 diabetes, and impairs brain development in children even at concentrations that don't trigger visible symptoms [2]. A telltale sign of chronic exposure is Mees' lines — white bands across the fingernails — and a distinctive patchy darkening of the skin [3]. Children absorb a higher percentage of what they ingest, making them especially vulnerable.

Who Is at Risk

People on private well water in the Northeast, Midwest, and Mountain West face the highest drinking-water risk and should test their wells every 1–3 years [1]. Infants who drink formula mixed with well water, and young children who spend time on old CCA-treated decks, face elevated exposures. Frequent rice consumers — particularly those who eat rice-based infant cereals — should diversify grains [2]. Workers in mining, smelting, electronics manufacturing, and wood preservation face occupational exposure. Pregnant women are at heightened risk because arsenic crosses the placenta.

How to Lower Your Exposure

Test your well water annually for arsenic (less than 10 ppb is the federal limit, but below 5 ppb is safer for children) [1]. Install a certified reverse-osmosis or activated-alumina filter on your drinking and cooking water — simple carbon filters do not remove arsenic. Cook rice in a large volume of water (6:1 ratio) and drain the excess to reduce arsenic content by up to 50% [2]. Limit apple and grape juice for young children. If you have pre-2004 pressure-treated wood on a deck, seal it annually and wash hands after touching it; consider replacing sections near where children play. Eat a varied diet — selenium from seafood and Brazil nuts can help your body process arsenic [3]. If you work in smelting or mining, wear NIOSH-approved respiratory protection and change clothes before leaving the worksite.

References

  1. [1]Mazumder DN. Chronic arsenic toxicity: clinical features, epidemiology, and treatment. J Environ Sci Health C. 2008;26(4):305-43. https://doi.org/10.1080/10590500802279700
  2. [2]Meharg AA, Zhao FJ. Arsenic & Rice. Springer; 2012. https://link.springer.com/book/10.1007/978-94-007-2947-6
  3. [3]Smith AH, et al. Contamination of drinking-water by arsenic in Bangladesh. Bull World Health Organ. 2000;78(9):1093-103. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2560840/
  4. [4]EPA. Arsenic in Drinking Water. https://www.epa.gov/ground-water-and-drinking-water/arsenic-drinking-water

Recovery & Clinical Information

Body Half-Life

Inorganic arsenic clears from blood within 2-4 days, but the story doesn't end there. Chronic exposure deposits arsenic in keratin-rich tissues — hair, nails, and skin — where it can be detected for months. Methylated arsenical metabolites persist in urine for days after a single exposure, but long-term tissue stores in skin (hyperkeratosis plaques) and potentially the liver accumulate with ongoing exposure. Hair arsenic reflects the prior 3 months of exposure; nail arsenic the prior 6-12 months [1].

Testing & Biomarkers

Urine arsenic speciation is the best measure of recent (past 2-3 days) inorganic arsenic intake — request 'speciated arsenic' not just total arsenic, as seafood contains harmless organic arsenobetaine that inflates total arsenic counts [1]. Hair or nail arsenic levels indicate longer-term exposure and can document historical exposure even years later. Serum arsenic is not useful for chronic low-level exposure. Most integrative medicine physicians and occupational health clinics can order urinary arsenic speciation [2].

Interventions

Removing the source of exposure — contaminated water, rice, or occupational contact — is the single most effective intervention; blood and urine levels fall sharply within days [1]. Folate-rich diet (leafy greens, legumes) supports arsenic methylation and excretion — folate is a cofactor for the enzymes that convert inorganic arsenic to less toxic methylated forms [2]. Selenium competes with arsenic at some metabolic steps and may reduce toxicity; Brazil nuts (1-2/day) are a practical food source. For high-level exposure, medical chelation with DMSA (succimer) or DMPS reduces body burden under physician supervision [1].

Recovery Timeline

After stopping exposure to contaminated water, inorganic arsenic in urine drops by 50% within 3-4 days [1]. Blood arsenic normalizes within 1-2 weeks. Hair and nail arsenic levels — reflecting past exposure — will grow out over 3-9 months as new keratin replaces old. Existing skin lesions (hyperkeratosis, Mees' lines) can take 1-3 years to fully resolve. Chronic arsenic-associated health effects such as neuropathy may persist or improve only partially even after exposure stops [2].

Recovery References

  1. [1]Hughes MF (2002). Arsenic toxicity and potential mechanisms of action. Toxicology Letters. https://doi.org/10.1016/S0378-4274(02)00084-X
  2. [2]ATSDR (2007). Toxicological Profile for Arsenic. https://www.atsdr.cdc.gov/toxprofiles/tp2.pdf

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