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CAS 3825-26-1

Ammonium perfluorooctanoate

Potential EDCPFAS

Ammonium perfluorooctanoate (APFO) is a PFAS used to make nonstick and stain‑resistant fluoropolymers. In the body and environment it becomes PFOA, a long‑lasting pollutant linked to immune, liver, and cancer harms [1][3].

Where It Comes From

Fluoropolymer (e.g., PTFE) manufacturing aid; releases from industrial waste, firefighting foams, and treated products [1][2].

How You Are Exposed

Drinking water near plants or bases, fish from contaminated waters, indoor dust, and workplaces; it can cross the placenta and enter breast milk [1][2].

Why It Matters

Persists and builds up; linked to higher cholesterol, lower vaccine response, liver changes, pregnancy‑induced hypertension, and lower birth weight; PFOA is an IARC Group 1 carcinogen (kidney/testicular) [1][3][5].

Who Is at Risk

Fluoropolymer workers; communities near PFAS facilities or firefighting training sites; pregnant people, fetuses, infants, and high fish consumers [1][2].

How to Lower Your Exposure

Use alternate water or certified filters (activated carbon or reverse osmosis), follow fish advisories, choose PFAS‑free/stain‑resistant‑free products, wet‑mop/HEPA vacuum dust, and follow workplace PFAS controls [1][2][4].

References

  1. [1]ATSDR. Toxicological Profile for Perfluoroalkyls (PFAS). 2021.
  2. [2]U.S. EPA. PFAS: Basic Information and Health Effects. 2022–2024.
  3. [3]IARC. Monographs Vol 131 Press Release: PFOA carcinogenic to humans (Group 1). 2023.
  4. [4]U.S. EPA. National Primary Drinking Water Regulation for PFAS (PFOA MCL = 4 ppt). 2024.
  5. [5]NTP. Monograph on Immunotoxicity Associated with PFOA or PFOS. 2016.

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