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CAS 70225-16-0

1-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, compd. with 2,2'-iminobis[ethanol] (1:1)

This industrial surfactant is a salt of perfluorohexane sulfonic acid (PFHxS, a PFAS) and diethanolamine. It has been used in firefighting foams and metal-plating processes; it matters because PFHxS persists, builds up in people, and is linked to health harms [1].

Where It Comes From

Manufacture/use of AFFF firefighting foams, chrome-plating mist suppressants, and stain-/water-repellent treatments; in water it dissociates to PFHxS [1].

How You Are Exposed

Drinking contaminated water near airports, military sites, plating shops, or PFAS facilities; eating food or dust with PFAS; workplace contact via air/skin [1][3].

Why It Matters

PFHxS has a long human half-life (~8 years) and studies associate exposure with higher cholesterol, liver enzyme changes, reduced vaccine response, and thyroid/developmental effects [1][3].

Who Is at Risk

Residents with PFAS-contaminated water; firefighters and plating/PFAS-industry workers; pregnant people, fetuses, and infants (PFHxS crosses the placenta and is found in breast milk) [1][3].

How to Lower Your Exposure

Use alternative water or NSF-certified PFAS filters (activated carbon or reverse osmosis), follow local advisories, reduce indoor dust (wet-wiping, HEPA vacuum), choose PFAS-free products when possible, and use workplace PPE/hygiene. Breastfeeding has many benefits; discuss concerns with your clinician [1][2][3].

References

  1. [1]ATSDR. Toxicological Profile for Perfluoroalkyls (PFAS). 2021. https://www.atsdr.cdc.gov/toxprofiles/tp200.pdf
  2. [2]U.S. EPA. Home Water Treatment Units That May Reduce PFAS in Drinking Water. 2022. https://www.epa.gov/system/files/documents/2022-06/drinking-water-adv-fact-sheet-pfas-home-water-treatment.pdf
  3. [3]CDC. Biomonitoring Summary: Perfluorohexane Sulfonic Acid (PFHxS). https://www.cdc.gov/biomonitoring/PFHxS_BiomonitoringSummary.html

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