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CAS 57-97-6

7,12-Dimethylbenz[a]Anthracene

Potential EDCCarcinogenMutagenTeratogen

7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) mainly used in research because it strongly causes tumors in animals [2]. In everyday environments, it may occur at very low levels with other PAHs in smoke and soot from burning fuels and materials [1].

Where It Comes From

Incomplete combustion (vehicle exhaust, wood/coal smoke, wildfires), tobacco smoke, and charred or smoked foods; also handled in research labs [1][2].

How You Are Exposed

Breathing smoke or exhaust, eating heavily charred foods, or getting soot/contaminated soil on your skin; lab exposures can occur if handling DMBA [1][2].

Why It Matters

PAH mixtures are linked to cancer in people, and DMBA causes DNA damage and tumors in animals; reducing exposure lowers long-term risk [1][2]. Short-term contact may irritate skin and eyes [1].

Who Is at Risk

People who smoke or breathe secondhand smoke; those near heavy traffic, certain industries, or wildfires; firefighters, asphalt/foundry workers, grill cooks; lab staff working with DMBA [1][2].

How to Lower Your Exposure

Don’t smoke and avoid secondhand smoke; use ventilation and avoid charring food; limit time in heavy smoke/exhaust; wash off soot and dust; follow lab/occupational PPE and hygiene [1].

References

  1. [1]ATSDR. Toxicological Profile for Polycyclic Aromatic Hydrocarbons (PAHs). U.S. Dept. of Health and Human Services, 2020.
  2. [2]IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Polynuclear aromatic compounds, Part 1: Chemical, environmental and experimental data. Vol. 32, International Agency for Research on Cancer.

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