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CAS 99-59-2

5-Nitro-o-anisidine (2-Methoxy-5-nitroaniline)

5-Nitro-o-anisidine is a man-made aromatic amine used mainly to make dyes and pigments. It is toxic; contact or breathing its dust can irritate skin, eyes, and airways, so it should be handled with care [1][2].

Where It Comes From

Produced as an intermediate for azo dyes/pigments; can appear as an impurity or by-product in dye manufacture and wastewater [1][2].

How You Are Exposed

Mostly at work—skin contact or inhalation when weighing, mixing, or cleaning; residents near facilities may be exposed via air or water; exposure from finished goods is expected to be low [1][2].

Why It Matters

Harmful if swallowed or inhaled; causes eye/skin irritation; harmful to aquatic life; human data on long-term effects are limited [2].

Who Is at Risk

Workers handling powders or wet batches; small shops without good ventilation or PPE; communities near poorly controlled releases [1][2].

How to Lower Your Exposure

Use closed systems, local exhaust, gloves, goggles, and protective clothing; wash up after work and prevent take-home dust; prevent releases and treat wastewater; at home, avoid handling raw dye powders and check local water reports if you live near plants [1][2].

References

  1. [1]U.S. EPA, CompTox Chemicals Dashboard: 2-Methoxy-5-nitroaniline (CASRN 99-59-2).
  2. [2]European Chemicals Agency (ECHA), 2-methoxy-5-nitroaniline — Brief Profile/Registered Substances.

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