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CAS 56-49-5

3-Methylcholanthrene

Potential EDCCarcinogenMutagen

3-Methylcholanthrene is a toxic polycyclic aromatic hydrocarbon (PAH) used mainly in research. It has caused cancer in animals and is classified by IARC as possibly carcinogenic to humans (Group 2B) [1].

Where It Comes From

Made for laboratory use; can form in tiny amounts during incomplete burning of organic material (vehicle exhaust, tobacco/wood smoke, coal tar/soot) [2][3].

How You Are Exposed

Most people have very low exposure. Possible routes include breathing smoky air or tobacco smoke, or contacting soot; researchers may be exposed when handling it [2][3].

Why It Matters

PAHs like 3‑methylcholanthrene can damage DNA and may raise cancer risk with long-term exposure [1][2].

Who Is at Risk

Smokers and people exposed to secondhand smoke; those near heavy traffic or industrial combustion; people who frequently eat heavily charred foods; and lab workers who use this chemical [2][3].

How to Lower Your Exposure

Avoid tobacco smoke and smoky air; use clean-burning stoves and good ventilation; reduce charring when grilling; and in labs, use fume hoods, closed systems, and proper PPE [2][3].

References

  1. [1]IARC Monographs. 3‑Methylcholanthrene, Group 2B (possibly carcinogenic). International Agency for Research on Cancer. https://monographs.iarc.who.int/list-of-classifications
  2. [2]ATSDR. Toxicological Profile for Polycyclic Aromatic Hydrocarbons (PAHs). Agency for Toxic Substances and Disease Registry, 2020. https://www.atsdr.cdc.gov/toxprofiles/tp69.pdf
  3. [3]WHO/IPCS. Environmental Health Criteria 202: Selected Non-heterocyclic Polycyclic Aromatic Hydrocarbons, 1998. World Health Organization. https://inchem.org/documents/ehc/ehc/ehc202.htm

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