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CAS 460-35-5

3-Chloro-1,1,1-trifluoropropane (HCFC-253fb)

This is a hydrochlorofluorocarbon (HCFC) used mainly as a specialty refrigerant and foam‑blowing agent. It matters because HCFCs deplete the ozone layer, add to climate change, and high levels can harm your health [1][2].

Where It Comes From

Produced for refrigeration and foam manufacturing; released by leaks during production, use, servicing, or disposal of equipment [1].

How You Are Exposed

Mostly by breathing vapors in workplaces or near leaking equipment; liquid contact can intensely chill skin/eyes; in confined or low‑lying areas, vapors can displace oxygen [2][3].

Why It Matters

Short‑term high exposure can cause dizziness, headache, nausea, or loss of consciousness; direct contact with the cold liquid can cause frostbite. As an HCFC, it also depletes ozone [1][2][3].

Who Is at Risk

HVAC and foam‑manufacturing workers; people working in poorly ventilated or confined spaces; bystanders during indoor leaks [2].

How to Lower Your Exposure

Maintain equipment and fix leaks promptly; ventilate areas; avoid confined spaces when a leak is suspected; use EPA‑certified technicians for service and refrigerant recovery; wear appropriate PPE and follow safety instructions [1][2].

References

  1. [1]U.S. EPA. Phaseout of Hydrochlorofluorocarbons (HCFCs). U.S. Environmental Protection Agency.
  2. [2]U.S. EPA. Refrigerant Safety and Safe Handling under Section 608. U.S. Environmental Protection Agency.
  3. [3]CDC/NIOSH. NIOSH Pocket Guide to Chemical Hazards: Chlorodifluoromethane (R‑22). Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health.

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