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CAS 612-83-9

3,3'-Dichlorobenzidine dihydrochloride

This toxic industrial chemical is used to make certain pigments and dyes for printing inks, paints, and plastics. It matters because long-term exposure can increase cancer risk, mainly seen in workers and near contaminated sites [1][2][3].

Where It Comes From

Made and used in dye/pigment manufacturing; can enter air, water, or soil from industrial releases and waste disposal [1].

How You Are Exposed

Breathing dust or vapors at work, skin contact with powders or contaminated surfaces, or contact with contaminated soil/sediment or water near facilities or waste sites [1][5].

Why It Matters

Classified as reasonably anticipated to cause cancer by NTP and possibly carcinogenic by IARC; evidence includes bladder and liver tumors (mostly in animals). It can also irritate skin/eyes and affect the liver [1][2][3][4].

Who Is at Risk

Workers making or using dyes/pigments, maintenance and cleanup crews, waste handlers, and people living near contaminated sites [1][5].

How to Lower Your Exposure

At work, use closed systems, local exhaust, protective gloves/clothing, and wash-up routines. In communities, heed site advisories, avoid disturbing contaminated soil/sediment, and keep indoor dust down with wet cleaning [1][5].

References

  1. [1]ATSDR. Toxicological Profile for 3,3'-Dichlorobenzidine (incl. dihydrochloride).
  2. [2]NTP. Report on Carcinogens: 3,3'-Dichlorobenzidine (and salts).
  3. [3]IARC Monographs. 3,3'-Dichlorobenzidine and its salts (Group 2B).
  4. [4]EPA IRIS. 3,3'-Dichlorobenzidine assessment.
  5. [5]CDC/NIOSH. Pocket Guide to Chemical Hazards: 3,3'-Dichlorobenzidine dihydrochloride.

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