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CAS 422-56-0

3,3-Dichloro-1,1,1,2,2-pentafluoropropane (HCFC-225ca)

HCFC-225ca is a man‑made solvent once widely used for precision cleaning (electronics, aerospace). It depletes the ozone layer and contributes to climate change, so its use is tightly restricted and being phased out in the U.S. [1].

Where It Comes From

Industrial chemical used mainly as a precision‑cleaning solvent and in some specialty aerosol and maintenance applications; releases can occur from degreasing operations and equipment leaks [1][2].

How You Are Exposed

Mostly by breathing vapors at work during cleaning, maintenance, or handling; less commonly from indoor air in places where it’s used or near industrial sources [1][2].

Why It Matters

Ozone‑depleting substance and greenhouse gas under EPA regulation [1]. Short‑term exposure can cause headache, dizziness, drowsiness, and eye/skin irritation; very high levels can depress the central nervous system and cause unconsciousness [3].

Who Is at Risk

Workers in electronics/aerospace cleaning and similar shops, especially in poorly ventilated areas; people with heart or lung conditions may be more sensitive to solvent vapors [2][3].

How to Lower Your Exposure

Substitute safer cleaners; use closed systems and local exhaust; ensure good ventilation; follow EPA/employer controls; wear appropriate gloves/eye protection; review the Safety Data Sheet [1][3].

References

  1. [1]U.S. EPA. Phaseout of HCFCs (Ozone Layer Protection) and SNAP listings for HCFC‑225ca/cb.
  2. [2]U.S. EPA. Risk Screen on Substitutes in Solvent Cleaning: HCFC‑225ca/cb.
  3. [3]CDC/NIOSH. Solvents – Workplace Safety and Health Topic.

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