2-Chloro-1,1,1-trifluoroethane (HCFC-133a)

Production and use in refrigeration, foam blowing, and as a feedstock for other fluorochemicals; leaks during equipment servicing or disposal [1][3].

Breathing vapors near leaks in poorly ventilated areas (mechanical rooms, workshops) or during manufacturing/servicing; skin or eye contact with the cold liquid [2].

Short-term inhalation can cause headache, dizziness, and drowsiness; very high levels can displace oxygen and may trigger irregular heartbeat. Liquid contact can cause frostbite. It also depletes stratospheric ozone and contributes to climate change [1][2][3].

HVAC and foam workers, fluorochemical manufacturing workers, and anyone in enclosed spaces near leaks; people with heart or lung conditions may be more sensitive [1][2].

Use certified technicians; promptly fix leaks and recover refrigerant; ensure good ventilation; never vent refrigerants; transition to non‑ozone‑depleting alternatives as regulations require [1][3].