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CAS 39156-41-7

2,4-Diaminoanisole sulfate

2,4-Diaminoanisole sulfate is a synthetic dye ingredient formerly used in some permanent hair-color products. It matters because health agencies link it to cancer concerns and to exposures in hairdressing work [1][2].

Where It Comes From

Made for use in oxidative hair dyes and related cosmetic dye formulations [1].

How You Are Exposed

Mainly through skin contact when mixing or applying hair dye; smaller amounts by breathing vapors or aerosols in salons or during manufacturing [1][2].

Why It Matters

IARC classifies 2,4-diaminoanisole and its sulfate as possibly carcinogenic to humans (Group 2B), based on sufficient evidence in animals. Occupational exposures in hairdressing are carcinogenic to humans (Group 1) [1][2].

Who Is at Risk

Salon workers and barbers; frequent at‑home users of permanent hair dyes; workers who make or handle dye ingredients [2].

How to Lower Your Exposure

Choose products that do not list 2,4‑diaminoanisole (or its sulfate); wear gloves and avoid skin contact; mix/apply in well‑ventilated areas; follow package directions and wash skin promptly after contact.

References

  1. [1]IARC Monographs, Volume 57 (1993): Occupational Exposures of Hairdressers and Barbers and Hair Colourants; Some Hair Dyes, Cosmetic Colourants, Industrial Dyes and Related Exposures. World Health Organization.
  2. [2]IARC Monographs, Volume 100F (2012): Chemical Agents and Related Occupations — Occupational exposures in hairdressing. World Health Organization.

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