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CAS 94-11-1

2,4-D isopropyl ester

2,4-D isopropyl ester is a weed-killing ingredient used on farms, roadsides, and lawns. It quickly breaks down to 2,4-D; high or repeated exposure can irritate eyes/skin and affect the nervous system, and cancer evidence is mixed [1][2][3].

Where It Comes From

Spraying of crops, turf, and rights-of-way; ester forms can vaporize and drift. In the environment and body, it converts to 2,4-D [1][2].

How You Are Exposed

Mixing/spraying products; touching treated grass/crops; breathing spray drift or vapors; residues on food, in water, and in house dust after lawn care [1][4][5].

Why It Matters

Short-term effects include irritation, nausea, headache, and weakness; severe poisonings can affect muscles and kidneys [1]. Long-term: thyroid and developmental effects seen in animals at high doses. IARC: possibly carcinogenic (Group 2B); EPA: not likely carcinogenic [2][3].

Who Is at Risk

Applicators and farmworkers; nearby residents; children and pets on recently treated lawns; people applying without protective gear [1][2].

How to Lower Your Exposure

Follow label directions; wear gloves, long sleeves, and eye protection; avoid spraying near homes/water on hot, windy days; stay off treated areas until dry and follow any re-entry times; close windows during nearby spraying; wash produce, remove shoes, and clean floors to reduce tracked-in residues [2][4][5].

References

  1. [1]ATSDR. Toxicological Profile for 2,4-Dichlorophenoxyacetic Acid (2,4-D). 2020.
  2. [2]U.S. EPA. Interim Registration Review Decision for 2,4-D. 2020.
  3. [3]IARC. 2,4-D. IARC Monographs, Vol. 113. 2017.
  4. [4]WHO. 2,4-D in Drinking-water: Background document for WHO Guidelines for Drinking-water Quality. 2003/2011 update.
  5. [5]CDC. National Biomonitoring Program: 2,4-D Biomonitoring Summary. Updated 2017/2022.

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