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CAS 422-48-0

2,3-dichloro-1,1,1,2,3-pentafluoropropane (HCFC-225ba)

HCFC-225ba is a hydrochlorofluorocarbon once used as a precision-cleaning solvent and in specialty aerosol/refrigeration products. It matters because HCFCs deplete the ozone layer and high levels can affect the nervous system and heart rhythm [1][2].

Where It Comes From

Industrial production and past use for electronics/metal cleaning; legacy equipment and lab stocks; phased out or heavily restricted in many applications [1].

How You Are Exposed

Mainly by breathing vapors at work during cleaning, degreasing, or maintenance; less commonly from spills or poorly ventilated spaces; general public exposure is low due to phaseout [1][2].

Why It Matters

Short-term high concentrations can cause dizziness and drowsiness and may trigger irregular heartbeat (cardiac sensitization); can irritate eyes/skin; it’s an ozone‑depleting substance regulated by EPA [1][2].

Who Is at Risk

Workers in vapor-degreasing/precision cleaning and service technicians for legacy systems; people with heart disease or on stimulants/epinephrine may be more sensitive to arrhythmias [2].

How to Lower Your Exposure

Use closed systems and local exhaust ventilation, choose EPA SNAP‑accepted alternatives, follow safety data sheets, avoid confined spaces, wear proper PPE, and use licensed ODS handling/disposal [1][3].

References

  1. [1]U.S. EPA. Phaseout of Hydrochlorofluorocarbons (HCFCs).
  2. [2]OECD. SIDS Initial Assessment Report: HCFC‑225ca/cb (precision-cleaning solvents): health and environmental hazards.
  3. [3]U.S. EPA SNAP Program. Solvent Cleaning Sector: Approved alternatives and best practices.

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