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CAS 1746-01-06

2,3,7,8-TCDD

Organic Chemicals, except for PFASPesticides

2,3,7,8-TCDD is the most toxic member of the dioxin family. It forms unintentionally during certain industrial processes and burning, and it builds up in the environment and body fat [1][2].

Where It Comes From

Waste incineration, metal smelting, some herbicide/chemical production, past chlorine bleaching of paper, and backyard trash burning [1][2].

How You Are Exposed

Mainly by eating animal fats (meat, dairy, fish). Also from contaminated soil or dust, air near burning/incinerators, and it can pass to infants during breastfeeding [1][2].

Why It Matters

Known human carcinogen; can harm the immune, reproductive, and endocrine systems; causes chloracne; linked to developmental effects. It persists in people for years (half-life about 7–11 years) [1][3][4].

Who Is at Risk

Workers in incineration/chemical production; people near contaminated sites; subsistence or high consumers of local fish/wild game; fetuses, infants, and pregnant people [1][2].

How to Lower Your Exposure

Follow local fish/game advisories; trim fat from meat and choose low‑fat dairy; avoid burning trash; reduce dust at home (wet‑wiping, HEPA vacuum); follow cleanup guidance at contaminated sites [1][2][5].

References

  1. [1]ATSDR. ToxFAQs for Chlorinated Dibenzo‑p‑Dioxins (CDDs). Agency for Toxic Substances and Disease Registry. https://www.atsdr.cdc.gov/toxfaqs/tfacts104.pdf
  2. [2]WHO. Dioxins and their effects on human health. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/dioxins-and-their-effects-on-human-health
  3. [3]IARC. 2,3,7,8‑Tetrachlorodibenzo‑p‑dioxin. IARC Monographs Vol. 100F. https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs/A-Review-of-Human-Carcinogens-Chemical-Agents-and-Related-Occupations-2012
  4. [4]NTP. Report on Carcinogens: 2,3,7,8‑TCDD (Known to be a human carcinogen). https://ntp.niehs.nih.gov/research/roc
  5. [5]EPA. Learn about Dioxins. U.S. Environmental Protection Agency. https://www.epa.gov/dioxin

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