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CAS 5522-43-0

1-Nitropyrene

1-Nitropyrene is a toxic nitro-PAH formed mainly by diesel combustion and found on fine airborne particles [1][3]. It can damage DNA and is classified as possibly carcinogenic to humans (IARC Group 2B); animal studies show it causes tumors (NTP) [1][2].

Where It Comes From

Diesel engine exhaust; formed during combustion and by nitration of pyrene in air; smaller amounts from other high‑temperature burning [1][3][4].

How You Are Exposed

Breathing air near traffic, idling trucks/buses, ports/railyards; indoor air infiltrating from nearby roads or attached garages; jobs using diesel equipment [3][4][5].

Why It Matters

Sticks to PM2.5 that reaches deep lungs; mutagenic with DNA adducts; causes tumors in animals; human evidence limited but concerning [1][2][3].

Who Is at Risk

Drivers, mechanics, dock/rail/mining workers; people living near busy roads or truck routes; children, pregnant people, and those with heart/lung disease [3][4][5].

How to Lower Your Exposure

Avoid diesel exhaust and idling; pick routes/times with less traffic; use HEPA air cleaners and close windows during peaks; ventilate garages; workplaces should use exhaust controls and follow NIOSH guidance [3][4][6].

References

  1. [1]IARC Monographs, Vol. 46: Diesel and Gasoline Engine Exhausts and Some Nitroarenes (incl. 1‑Nitropyrene). IARC, 1989.
  2. [2]NTP. Toxicology and Carcinogenesis Studies of 1‑Nitropyrene (TR‑416). U.S. DHHS, 1993.
  3. [3]U.S. EPA. Health Assessment Document for Diesel Engine Exhaust. EPA/600/8‑90/057F, 2002.
  4. [4]WHO. WHO Guidelines for Indoor Air Quality: Selected Pollutants (PAHs/nitro‑PAHs). 2010.
  5. [5]ATSDR. ToxFAQs: Polycyclic Aromatic Hydrocarbons (PAHs). 2020.
  6. [6]CDC/NIOSH. Diesel Exhaust in the Workplace: Exposure Evaluation and Control. 2013.

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