Where It Comes From
Leaks/releases from older refrigeration and air-conditioning equipment, foam production, and aerosol uses; emissions during servicing and disposal [1].
How You Are Exposed
Breathing vapors near leaking equipment or in confined, poorly ventilated spaces; skin/eye contact with the very cold liquid [3][4].
Why It Matters
Short-term high levels can cause dizziness, headache, and poor coordination; very high concentrations can displace oxygen and lead to fainting or suffocation. Liquid contact can cause frostbite; in fires it can break down into irritating, toxic gases (e.g., hydrogen fluoride) [3][4]. It is an ozone‑depleting substance and a greenhouse gas; production is being phased out under the Clean Air Act and Montreal Protocol [1][2].
Who Is at Risk
HVAC/refrigeration technicians, foam and aerosol workers, and people near leaking or improperly serviced equipment in small rooms [1][3].
How to Lower Your Exposure
Use certified technicians for service and refrigerant recovery; ensure good ventilation; avoid enclosed spaces with suspected leaks; follow label/SDS guidance; replace with non‑ozone‑depleting alternatives when possible [1][2][3].
References
- [1]U.S. EPA. Phaseout of Class II Ozone-Depleting Substances (HCFCs). https://www.epa.gov/ozone-layer-protection/phaseout-class-ii-ozone-depleting-substances
- [2]U.S. EPA. Ozone-Depleting Substances (ODS) and Climate Impacts. https://www.epa.gov/ozone-layer-protection/ozone-depleting-substances
- [3]ATSDR/CDC. Medical Management Guidelines for Chlorofluorocarbon Refrigerants (CFCs/HCFCs). https://wwwn.cdc.gov/TSP/MMG/MmgIndex.aspx
- [4]CDC/NIOSH. Pocket Guide to Chemical Hazards: HCFC refrigerants (e.g., 2‑chloro-1,1,1,2‑tetrafluoroethane). https://www.cdc.gov/niosh/npg/