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CAS 108-45-2

1,3-Phenylenediamine

1,3-Phenylenediamine (m-phenylenediamine) is an industrial chemical used to make dyes, epoxy resins, and aramid fibers. It can irritate the skin and eyes and can cause allergic skin reactions; it is not classifiable as to its carcinogenicity in humans [1][2][3].

Where It Comes From

Manufactured for dye intermediates, epoxy curing agents, and aramid fibers; can be released to air and wastewater from industrial use [1].

How You Are Exposed

Breathing workplace dust or vapors; skin contact during production or use; touching uncured materials; living near facilities with releases [1][2].

Why It Matters

Causes skin/eye irritation and allergic contact dermatitis; inhalation can irritate nose/throat; repeated exposure may lead to sensitization (stronger reactions at lower doses) [2]. EPA/IARC: not classifiable for cancer [1][3].

Who Is at Risk

Workers in dye, resin, and aramid-fiber manufacturing or labs; people already sensitized to aromatic amines [1][2].

How to Lower Your Exposure

Use chemical-resistant gloves, goggles, and protective clothing; ensure local exhaust ventilation; avoid skin contact and wash after handling; follow workplace exposure limits; if sensitized, avoid further exposure [2].

References

  1. [1]U.S. EPA. 1,3-Benzenediamine (m-Phenylenediamine) Hazard Summary.
  2. [2]CDC/NIOSH. Pocket Guide to Chemical Hazards: m-Phenylenediamine (CAS 108-45-2).
  3. [3]IARC Monographs. Evaluation of carcinogenic risks for phenylenediamines: m-Phenylenediamine, not classifiable (Group 3).

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