Where It Comes From
Industrial HCFC uses (refrigeration, foam blowing, solvents); releases occur during manufacturing, equipment leaks, servicing, and disposal [2].
How You Are Exposed
Breathing vapors at work (HVAC, foam/fire‑suppression, chemical plants) or near leaking equipment in enclosed spaces; skin/eye contact with liquid can irritate [1][3].
Why It Matters
Can cause dizziness and drowsiness; very high levels may trigger dangerous heart rhythm changes and breathing problems. Repeated high exposure has caused liver effects with related HCFC‑123 [1][3]. It also depletes ozone and is a greenhouse gas [2].
Who Is at Risk
Workers handling HCFCs; people in poorly ventilated or confined areas; individuals with heart disease or on epinephrine/sympathomimetic drugs (greater arrhythmia risk) [1][3].
How to Lower Your Exposure
Prevent and repair leaks, use certified technicians, ventilate and monitor air at work, follow PPE and confined‑space procedures, and choose safer alternatives when feasible [2][3].
References
- [1]WHO/IPCS. CICAD 26: 2,2-Dichloro-1,1,1-trifluoroethane (HCFC‑123). 2000. https://inchem.org/documents/cicads/cicads/cicad26.htm
- [2]U.S. EPA. Phaseout of Class II Ozone‑Depleting Substances (HCFCs). https://www.epa.gov/ods-phaseout/phaseout-class-ii-ozone-depleting-substances-hydrochlorofluorocarbons-hcfcs
- [3]CDC/NIOSH. Pocket Guide to Chemical Hazards: HCFC‑123 (Ethane, 2,2‑dichloro‑1,1,1‑trifluoro‑). https://www.cdc.gov/niosh/npg/