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CAS 422-44-6

1,2-Dichloro-1,1,2,3,3-pentafluoropropane (HCFC-225bb)

HCFC-225bb is a man-made cleaning solvent formerly used in precision electronics and metal-part degreasing. It’s an ozone‑depleting hydrochlorofluorocarbon being phased out; high concentrations can irritate the airways and affect the nervous system [1][2][3].

Where It Comes From

Production and past use as a precision-cleaning and aerosol solvent; releases from older products and waste handling; emissions at facilities that used it [1][2].

How You Are Exposed

Breathing vapors at work; leaks from stored products; living or working near industrial sites; skin or eye contact with liquid. Vapors can accumulate in low areas and displace oxygen [3][4].

Why It Matters

Depletes the stratospheric ozone layer and contributes to climate change; short-term high exposure may cause dizziness, headache, and irregular heartbeat; liquid can cause frostbite on contact [1][3][4].

Who Is at Risk

Workers in electronics/metal cleaning or aerosol use; people in poorly ventilated or confined spaces; those with heart or lung conditions may be more sensitive [3][4].

How to Lower Your Exposure

Prefer EPA SNAP-listed alternatives; use local exhaust ventilation/closed systems; check for leaks; follow the SDS and wear gloves/eye protection; dispose of legacy stocks per EPA rules [1][2].

References

  1. [1]U.S. EPA. Phasing Out HCFCs to Protect the Ozone Layer. https://www.epa.gov/ods-phaseout
  2. [2]U.S. EPA. SNAP Program: Substitutes in Solvent Cleaning. https://www.epa.gov/snap/solvent-cleaning
  3. [3]ATSDR. ToxFAQs for Chlorodifluoromethane (HCFC‑22). https://www.atsdr.cdc.gov/toxfaqs/tfacts100.pdf
  4. [4]NOAA CAMEO Chemicals. 1,2-Dichloro-1,1,2,3,3-pentafluoropropane (CAS 422-44-6). https://cameochemicals.noaa.gov/

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