What they found
This study found that nearly all human serum/plasma samples contained at least one PFAS, with most showing complex mixtures rather than single compounds. The most common combination was detected in 26.1% of samples.
What they studied
Researchers evaluated PFAS combinations in 10,566 human serum/plasma samples to characterize co-positivity patterns, noting that mixtures may have additive or synergistic health effects. Samples were analyzed using targeted liquid chromatography-tandem mass spectrometry.
Takeaways
The findings emphasize the importance of considering PFAS as mixtures in biomonitoring and risk assessment.
About this paper
This study evaluated PFAS combinations in 10,566 human serum/plasma samples collected between December 2023 and December 2024. The analysis used targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) across two different PFAS panels. Continued evaluation of analytical scopes will be essential as new PFAS analogs emerge.