What they found
Tributyl citrate (TBC) aggravates colonic inflammation and promotes colitis-associated carcinogenesis in mice. Researchers identified 299 TBC-related targets, with 13 core targets linked to oxidative stress and inflammatory pathways.
What they studied
Researchers used animal experiments with a microplastic-induced colitis mouse model and an AOM/DSS-induced colorectal cancer mouse model. They investigated TBC's role in exacerbating intestinal inflammation and tumor formation.
Takeaways
The abstract focuses on the study's findings regarding TBC toxicity and mechanisms; it does not provide personal how-to steps for readers.
About this paper
This study combined network toxicology, molecular docking, and in vivo animal experiments. It provides a theoretical basis for understanding TBC's role in inflammation-associated colorectal cancer.