PFAS Disrupt Body's Core Regulators, Leading to Multi-Organ Toxicity

This review found that Per- and polyfluoroalkyl substances (PFAS) act as a central regulatory hub, interacting with nuclear receptors (NRs) to cause multi-organ toxicity. These interactions disrupt lipid metabolism, glucose regulation, and endocrine pathways.

Researchers reviewed how PFAS behave in realistic mixed-exposure scenarios, highlighting limitations of traditional toxicological models. They integrated evidence on PFAS interactions with key nuclear receptors and their subsequent molecular perturbations.

The abstract focuses on findings regarding PFAS mechanisms and health hazards; it does not give personal how-to steps for reducing exposure.

This is a review article that synthesizes current evidence on PFAS interactions with nuclear receptors from animal models and human epidemiological studies. It aims to improve understanding of multisystem effects at the molecular level.